The Effective Statistician - in association with PSI

The Effective Statistician - in association with PSI

The Effective Statistician - in association with PSI

Defining Clinical Trial Estimands: A Practical Guide for Study Teams with Examples including Regulatory Buy-in

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This is an extraordinary episode that takes us deep into the world of modern pharmaceutical research.

Today, we are embarking on a captivating journey guided by the insightful dialogue between me and Elena Polverejan.

Throughout this episode, we uncover the incredible potential of Estimands Framework, a revolutionary concept born from the collaborative efforts of brilliant minds dedicated to transforming clinical trials.

Join us as we delve into the origins of Estimands, discover its practical applications in the complex realm of depression studies, and witness the meticulous process of creating a practical guide that empowers research teams worldwide.

This conversation not only sheds light on the complexities of pharmaceutical research, but also reveals a blueprint for progress, illuminating a path towards more accurate, efficient, and impactful clinical trials.

So, listen now and get ready for an enlightening exploration into the future of pharmaceutical innovation while we discuss also about the following points:

Cross-Over Studies: When Do They Offer a Great Advantage?

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I'm thrilled to dive into a topic that has been untouched in the past 300 episodes - crossover studies. It's a classical design that offers unique advantages, yet it's often overlooked.

Joining me today is Markus Savli, a biostatistician with a diverse background in biomedical engineering, mathematics, and epidemiology. Together, we'll explore the intricacies of crossover studies and their applications in scientific research.

.A crossover study is a longitudinal study where subjects receive multiple treatments in a sequence. This design allows subjects to serve as their own controls, enhancing the ability to address confounding factors. Crossover studies are particularly valuable in scenarios where treatments need to be compared, and their effects measured over multiple periods.

Listen to this episode now while we walk through the following key concepts:

Do You Still Negotiate About Numbers of Tables?

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In the intricate world of statistics organizations, a common challenge often arises: how to balance increasing cost pressures while maintaining the quality and relevance of the produced tables. In this episode, I dive into this recurring scene, shedding light on the art of negotiation on the numbers of tables.

I also talk about the following important points:

Risk Mitigation for Statisticians

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In today's episode, I discuss the crucial topic of risk management in clinical trials with guest Jess Thompson. Jess, the founder of the Association of Clinical Research Project Managers, shares her extensive experience in the field, emphasizing the importance of proactive risk identification and collaborative communication within project teams.

The conversation delves into practical strategies for risk assessment, impact scoring, and contingency planning, highlighting the significance of involving all team members, including statisticians, in the risk management process.

We talk more about the following key points:

Ethical Guidelines for Statisticians - Why and What

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In this episode, I interview Katharina Schueller, a statistician and entrepreneur, to discuss the importance of ethical guidelines for statisticians. Katharina shares her insights on the ethical aspects of statistics, the responsibilities of statisticians, and the relevance of the Declaration of Ethics by the International Statistics Institute (ISI). We explore various values, examples, and practical applications related to ethical statistical practices.

Here are some more points we discuss:

Working in an Under-Resourced Environment and What to Do

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The modern working environment is defined by endless to-do lists, tight deadlines, and the expectation to do more with less. As employees struggle to manage the job responsibilities of 2 or 3 people, exhaustion happens first. Long working hours, with little to no downtime, lead to mental and physical fatigue. Working like this is harmful and not sustainable, but many of us keep going because of the fear of judgment, rejection, or missing out on a promotion. 

In this episode, I explore the steps that employees can take to prevent burnout and improve their overall experience at work.

Moving from SAS to R - Practical Tips Part 3

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Welcome to the third and last part of Moving from SAS to R where Thomas joined us again to talk about transitioning from SAS to R.

We also discuss the new SAS to R course of The Effective Statistician and you’ll learn, if this is the right course for you.

We provide a couple of learnings from the course for you to get an impression of what we cover in the course.

Click here to get to the course overview!

We also discuss the following points:

Moving from SAS to R - Practical Tips Part 2

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This episode is the second part of Moving from SAS to R with Thomas.

We also discuss the new SAS to R course of The Effective Statistician and you’ll learn, if this is the right course for you.

We provide a couple of learnings from the course for you to get an impression of what we cover in the course.

Click here to get to the course overview!
https://theeffectivestatisticianleadershipprogram.teachable.com/p/open-source-programming

We also discuss the following points:

Moving from SAS to R - Practical Tips Part 1

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The use of R in the pharmaceutical and healthcare industry has been increasing over the years, with larger companies like Roche adopting it as their primary statistical software. Others like GSK, NovoNordisk, and Merck make heavy investments into it. 

In this episode, Thomas Neitmann discusses various lessons from his career within pharma and the role R played in it. He provides insights into how to start with R and what are key differences to SAS.

We also discuss the new SAS to R course of The Effective Statistician and you'll learn, if this is the right course for you.

We provide a couple of learnings from the course for you to get an impression of what we cover in the course.

Click here to get to the course overview!

We also discuss the following points:

About this podcast

The podcast from statisticians for statisticians to have a bigger impact at work. This podcast is set up in association with PSI - Promoting Statistical Insight. This podcast helps you to grow your leadership skills, learn about ongoing discussions in the scientific community, build you knowledge about the health sector and be more efficient at work. This podcast helps statisticians at all levels with and without management experience. It is targeted towards the health, but lots of topics will be important for the wider data scientists community.

by Alexander Schacht and Benjamin Piske, biometricians, statisticians and leaders in the pharma industry

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